Tp53 Mutation Inhibits Ubiquitination and Degradation of WISP1 via Down-Regulation of Siah1 in Pancreatic Carcinogenesis

Tp53 Mutation Inhibits Ubiquitination and Degradation of WISP1 via Down-Regulation of Siah1 in Pancreatic Carcinogenesis

Wnt1 inducible signaling pathway protein-1 (WISP1) may play an important role in promoting carcinogenesis. However, the biological function and underlying mechanism of WISP1 in pancreatic carcinogenesis still remains enigmatic. In this study, immunochemistry staining showed that protein levels of WI...

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Bibliographic Details
Main Authors: Wei Wu, Xu Liu, Lumin Wei, Tong Li, Yi Zang, Yuting Qian, Tingting Bai, Juanjuan Li, Mingping Xie, Ying Zhu, Qi Wang, Lifu Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
WISP1
Tp53 mutation
Siah1
pancreatic cancer
carcinogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00857/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00857/full

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