Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57<sup>CDKN1C</sup> and TP53INP1 in mantle cell lymphoma

Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57<sup>CDKN1C</sup> and TP53INP1 in mantle cell lymphoma

<b>Objective</b> To explore the effect of dysregulation of epigenetic regulator EZH1 and EZH2 on the proliferation in MCL and the underlying mechanisms.<b>Methods</b> In this study, we elucidated the role of EZH1 and EZH2 overexpression by immunohistochemistry and correlated...

Full description

Bibliographic Details
Main Authors: Wei Li, Chengfeng Bi, Yating Han, Tian Tian, Xianhuo Wang, Huijing Bao, Xiaoying Xu, Xuhan Zhang, Lu Liu, Weiwei Zhang, Hai Gao, Huaqing Wang, Huilai Zhang, Bin Meng, Xi Wang, Kai Fu
Format: Article
Language:English
Published: China Anti-Cancer Association 2019-09-01
Series:Cancer Biology & Medicine
Subjects:
Mantle cell lymphoma
EZH1
EZH2
CRISPR/Cas9
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1451

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/1451

Similar Items