Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C-glycoside cleaving enzyme and an O- to C-glycoside isomerase

The C-glycosidic bond that connects the sugar moiety with aglycone is difficult to be broken or made due to its inert nature. The knowledge of C-glycoside breakdown and synthesis is very limited. Recently, the enzyme DgpA/B/C cascade from a human intestinal bacterium PUE was identified to specifical...

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Bibliographic Details
Main Authors: Pengfei He, Sha Wang, Sen Li, Siqi Liu, Shuqi Zhou, Jing Wang, Jiayue Tao, Dongdong Wang, Rufeng Wang, Wenfu Ma
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522002441