The role of Nurr1-miR-30e-5p-NLRP3 axis in inflammation-mediated neurodegeneration: insights from mouse models and patients’ studies in Parkinson’s disease

The role of Nurr1-miR-30e-5p-NLRP3 axis in inflammation-mediated neurodegeneration: insights from mouse models and patients’ studies in Parkinson’s disease

Abstract Nuclear receptor related-1 (Nurr1), a ligand-activated transcription factor, is considered a potential susceptibility gene for Parkinson’s disease (PD), and has been demonstrated to possess protective effects against inflammation-induced neuronal damage. Despite the evidence showing decreas...

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Bibliographic Details
Main Authors: Tianbai Li, Xiang Tan, Lulu Tian, Congcong Jia, Cheng Cheng, Xi Chen, Min Wei, Yuanyuan Wang, Yiying Hu, Qiqi Jia, Yang Ni, Murad Al-Nusaif, Song Li, Weidong Le
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Neuroinflammation
Subjects:
Parkinson’s disease
Nuclear receptor related-1
Nucleotide-binding domain-like receptor protein 3
miRNA-30e-5p
Interleukin-1β
Online Access:https://doi.org/10.1186/s12974-023-02956-x

Internet

https://doi.org/10.1186/s12974-023-02956-x

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