Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle

Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle

Abstract Background Amino acid availability stimulates protein synthesis via the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. In response to an increase in cellular amino acid availability, translocation of cytosolic mTORC1 to the lysosomal surface is required to stimulate m...

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Bibliographic Details
Main Authors: Ted G. Graber, Michael S. Borack, Paul T. Reidy, Elena Volpi, Blake B. Rasmussen
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Nutrition & Metabolism
Subjects:
Muscle
Protein synthesis
mTORC1
Chloroquine
Lysosome
Online Access:http://link.springer.com/article/10.1186/s12986-017-0187-1

Internet

http://link.springer.com/article/10.1186/s12986-017-0187-1

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