Metformin combats high glucose-induced damage to the osteogenic differentiation of human periodontal ligament stem cells via inhibition of the NPR3-mediated MAPK pathway

Metformin combats high glucose-induced damage to the osteogenic differentiation of human periodontal ligament stem cells via inhibition of the NPR3-mediated MAPK pathway

Abstract Background High glucose-induced damage to the osteogenic differentiation of human periodontal ligament stem cells (PDLSCs) has long been a challenge to periodontal regeneration for diabetic individuals. Metformin is an anti-hyperglycemic drug that exhibits abundant biological activities ass...

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Bibliographic Details
Main Authors: Yi-Lin Zhang, Fen Liu, Zhi-Bang Li, Xiao-Tao He, Xuan Li, Rui-Xin Wu, Hai-Hua Sun, Shao-Hua Ge, Fa-Ming Chen, Ying An
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
High glucose
Metformin
Osteogenic differentiation
NPR3
MAPK pathway
Periodontal tissue regeneration
Online Access:https://doi.org/10.1186/s13287-022-02992-z

Internet

https://doi.org/10.1186/s13287-022-02992-z

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