Modulating tumour metabolism enhances gold nanoparticle radiosensitisation in HPV-negative head and neck cancer

Modulating tumour metabolism enhances gold nanoparticle radiosensitisation in HPV-negative head and neck cancer

Abstract Background Radiotherapy is a major therapeutic modality for locally advanced head and neck cancer. However, the effectiveness of radiotherapy is hindered by resistance mechanisms, most notably hypoxia, leading to unfavourable treatment outcomes. In this study, we investigate the radiosensit...

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Bibliographic Details
Main Authors: Jie Feng, Varun Pathak, Niall M. Byrne, Tongchuan Wang, Cancan Yin, Reinhold J. Medina, Jonathan A. Coulter
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Cancer Nanotechnology
Subjects:
Metabolic radiosensitisation
Atovaquone
Gold nanoparticles
Head and neck cancer
Online Access:https://doi.org/10.1186/s12645-023-00185-8

Internet

https://doi.org/10.1186/s12645-023-00185-8

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