The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation
G-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control cellular states in response to soluble extracellular cues. However, the modality of stimuli recognized through adhesion GPCR (aGPCR), the second largest class of the GPCR superfamily, is unresolved. Our study cha...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-05-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124715003836 |
| _version_ | 1818514210262351872 |
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| author | Nicole Scholz Jennifer Gehring Chonglin Guan Dmitrij Ljaschenko Robin Fischer Vetrivel Lakshmanan Robert J. Kittel Tobias Langenhan |
| author_facet | Nicole Scholz Jennifer Gehring Chonglin Guan Dmitrij Ljaschenko Robin Fischer Vetrivel Lakshmanan Robert J. Kittel Tobias Langenhan |
| author_sort | Nicole Scholz |
| collection | DOAJ |
| description | G-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control cellular states in response to soluble extracellular cues. However, the modality of stimuli recognized through adhesion GPCR (aGPCR), the second largest class of the GPCR superfamily, is unresolved. Our study characterizes the Drosophila aGPCR Latrophilin/dCirl, a prototype member of this enigmatic receptor class. We show that dCirl shapes the perception of tactile, proprioceptive, and auditory stimuli through chordotonal neurons, the principal mechanosensors of Drosophila. dCirl sensitizes these neurons for the detection of mechanical stimulation by amplifying their input-output function. Our results indicate that aGPCR may generally process and modulate the perception of mechanical signals, linking these important stimuli to the sensory canon of the GPCR superfamily. |
| first_indexed | 2024-12-11T00:12:40Z |
| format | Article |
| id | doaj.art-6ec3e70356a24eb7bf4ff6a7477b6427 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-11T00:12:40Z |
| publishDate | 2015-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-6ec3e70356a24eb7bf4ff6a7477b64272022-12-22T01:28:05ZengElsevierCell Reports2211-12472015-05-0111686687410.1016/j.celrep.2015.04.008The Adhesion GPCR Latrophilin/CIRL Shapes MechanosensationNicole Scholz0Jennifer Gehring1Chonglin Guan2Dmitrij Ljaschenko3Robin Fischer4Vetrivel Lakshmanan5Robert J. Kittel6Tobias Langenhan7Department of Neurophysiology, Institute of Physiology, University of Würzburg, Röntgenring 9, 97070 Würzburg, GermanyDepartment of Neurophysiology, Institute of Physiology, University of Würzburg, Röntgenring 9, 97070 Würzburg, GermanyDepartment of Neurophysiology, Institute of Physiology, University of Würzburg, Röntgenring 9, 97070 Würzburg, GermanyDepartment of Neurophysiology, Institute of Physiology, University of Würzburg, Röntgenring 9, 97070 Würzburg, GermanyDepartment of Neurophysiology, Institute of Physiology, University of Würzburg, Röntgenring 9, 97070 Würzburg, GermanyDepartment of Neurophysiology, Institute of Physiology, University of Würzburg, Röntgenring 9, 97070 Würzburg, GermanyDepartment of Neurophysiology, Institute of Physiology, University of Würzburg, Röntgenring 9, 97070 Würzburg, GermanyDepartment of Neurophysiology, Institute of Physiology, University of Würzburg, Röntgenring 9, 97070 Würzburg, GermanyG-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control cellular states in response to soluble extracellular cues. However, the modality of stimuli recognized through adhesion GPCR (aGPCR), the second largest class of the GPCR superfamily, is unresolved. Our study characterizes the Drosophila aGPCR Latrophilin/dCirl, a prototype member of this enigmatic receptor class. We show that dCirl shapes the perception of tactile, proprioceptive, and auditory stimuli through chordotonal neurons, the principal mechanosensors of Drosophila. dCirl sensitizes these neurons for the detection of mechanical stimulation by amplifying their input-output function. Our results indicate that aGPCR may generally process and modulate the perception of mechanical signals, linking these important stimuli to the sensory canon of the GPCR superfamily.http://www.sciencedirect.com/science/article/pii/S2211124715003836 |
| spellingShingle | Nicole Scholz Jennifer Gehring Chonglin Guan Dmitrij Ljaschenko Robin Fischer Vetrivel Lakshmanan Robert J. Kittel Tobias Langenhan The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation Cell Reports |
| title | The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation |
| title_full | The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation |
| title_fullStr | The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation |
| title_full_unstemmed | The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation |
| title_short | The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation |
| title_sort | adhesion gpcr latrophilin cirl shapes mechanosensation |
| url | http://www.sciencedirect.com/science/article/pii/S2211124715003836 |
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