Brain network hypersensitivity underlies pain crises in sickle cell disease
Abstract Sickle cell disease (SCD) is a genetic disorder causing painful and unpredictable Vaso-occlusive crises (VOCs) through blood vessel blockages. In this study, we propose explosive synchronization (ES) as a novel approach to comprehend the hypersensitivity and occurrence of VOCs in the SCD br...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-57473-5 |
| _version_ | 1827301178670579712 |
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| author | Pangyu Joo Minkyung Kim Brianna Kish Vidhya Vijayakrishnan Nair Yunjie Tong Ziyue Liu Andrew R. W. O’Brien Steven E. Harte Richard E. Harris UnCheol Lee Ying Wang |
| author_facet | Pangyu Joo Minkyung Kim Brianna Kish Vidhya Vijayakrishnan Nair Yunjie Tong Ziyue Liu Andrew R. W. O’Brien Steven E. Harte Richard E. Harris UnCheol Lee Ying Wang |
| author_sort | Pangyu Joo |
| collection | DOAJ |
| description | Abstract Sickle cell disease (SCD) is a genetic disorder causing painful and unpredictable Vaso-occlusive crises (VOCs) through blood vessel blockages. In this study, we propose explosive synchronization (ES) as a novel approach to comprehend the hypersensitivity and occurrence of VOCs in the SCD brain network. We hypothesized that the accumulated disruptions in the brain network induced by SCD might lead to strengthened ES and hypersensitivity. We explored ES's relationship with patient reported outcome measures (PROMs) as well as VOCs by analyzing EEG data from 25 SCD patients and 18 matched controls. SCD patients exhibited lower alpha frequency than controls. SCD patients showed correlation between frequency disassortativity (FDA), an ES condition, and three important PROMs. Furthermore, stronger FDA was observed in SCD patients with a higher frequency of VOCs and EEG recording near VOC. We also conducted computational modeling on SCD brain network to study FDA's role in network sensitivity. Our model demonstrated that a stronger FDA could be linked to increased sensitivity and frequency of VOCs. This study establishes connections between SCD pain and the universal network mechanism, ES, offering a strong theoretical foundation. This understanding will aid predicting VOCs and refining pain management for SCD patients. |
| first_indexed | 2024-04-24T16:18:40Z |
| format | Article |
| id | doaj.art-6ec4a414d51445dba80383c2da802b56 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T16:18:40Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6ec4a414d51445dba80383c2da802b562024-03-31T11:19:47ZengNature PortfolioScientific Reports2045-23222024-03-0114111310.1038/s41598-024-57473-5Brain network hypersensitivity underlies pain crises in sickle cell diseasePangyu Joo0Minkyung Kim1Brianna Kish2Vidhya Vijayakrishnan Nair3Yunjie Tong4Ziyue Liu5Andrew R. W. O’Brien6Steven E. Harte7Richard E. Harris8UnCheol Lee9Ying Wang10Department of Anesthesiology, Center for Consciousness Science, Center for the Study of Complex Systems, Michigan Psychedelic Center, University of MichiganDepartment of Anesthesiology, Center for Consciousness Science, Center for the Study of Complex Systems, Michigan Psychedelic Center, University of MichiganWeldon School of Biomedical Engineering, Purdue UniversityWeldon School of Biomedical Engineering, Purdue UniversityWeldon School of Biomedical Engineering, Purdue UniversityIndiana Center for Musculoskeletal Health, Indiana UniversityDivision of Hematology/Oncology, Department of Medicine, Indiana University School of MedicineDepartment of Anesthesiology, Chronic Pain and Fatigue Research Center, University of MichiganDepartment of Anesthesiology, Chronic Pain and Fatigue Research Center, University of MichiganDepartment of Anesthesiology, Center for Consciousness Science, Center for the Study of Complex Systems, Michigan Psychedelic Center, University of MichiganDivision of Hematology/Oncology, Department of Medicine, Indiana University School of MedicineAbstract Sickle cell disease (SCD) is a genetic disorder causing painful and unpredictable Vaso-occlusive crises (VOCs) through blood vessel blockages. In this study, we propose explosive synchronization (ES) as a novel approach to comprehend the hypersensitivity and occurrence of VOCs in the SCD brain network. We hypothesized that the accumulated disruptions in the brain network induced by SCD might lead to strengthened ES and hypersensitivity. We explored ES's relationship with patient reported outcome measures (PROMs) as well as VOCs by analyzing EEG data from 25 SCD patients and 18 matched controls. SCD patients exhibited lower alpha frequency than controls. SCD patients showed correlation between frequency disassortativity (FDA), an ES condition, and three important PROMs. Furthermore, stronger FDA was observed in SCD patients with a higher frequency of VOCs and EEG recording near VOC. We also conducted computational modeling on SCD brain network to study FDA's role in network sensitivity. Our model demonstrated that a stronger FDA could be linked to increased sensitivity and frequency of VOCs. This study establishes connections between SCD pain and the universal network mechanism, ES, offering a strong theoretical foundation. This understanding will aid predicting VOCs and refining pain management for SCD patients.https://doi.org/10.1038/s41598-024-57473-5 |
| spellingShingle | Pangyu Joo Minkyung Kim Brianna Kish Vidhya Vijayakrishnan Nair Yunjie Tong Ziyue Liu Andrew R. W. O’Brien Steven E. Harte Richard E. Harris UnCheol Lee Ying Wang Brain network hypersensitivity underlies pain crises in sickle cell disease Scientific Reports |
| title | Brain network hypersensitivity underlies pain crises in sickle cell disease |
| title_full | Brain network hypersensitivity underlies pain crises in sickle cell disease |
| title_fullStr | Brain network hypersensitivity underlies pain crises in sickle cell disease |
| title_full_unstemmed | Brain network hypersensitivity underlies pain crises in sickle cell disease |
| title_short | Brain network hypersensitivity underlies pain crises in sickle cell disease |
| title_sort | brain network hypersensitivity underlies pain crises in sickle cell disease |
| url | https://doi.org/10.1038/s41598-024-57473-5 |
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