Brain network hypersensitivity underlies pain crises in sickle cell disease

Brain network hypersensitivity underlies pain crises in sickle cell disease

Abstract Sickle cell disease (SCD) is a genetic disorder causing painful and unpredictable Vaso-occlusive crises (VOCs) through blood vessel blockages. In this study, we propose explosive synchronization (ES) as a novel approach to comprehend the hypersensitivity and occurrence of VOCs in the SCD br...

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Bibliographic Details
Main Authors:	Pangyu Joo, Minkyung Kim, Brianna Kish, Vidhya Vijayakrishnan Nair, Yunjie Tong, Ziyue Liu, Andrew R. W. O’Brien, Steven E. Harte, Richard E. Harris, UnCheol Lee, Ying Wang
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-03-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-024-57473-5

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