Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells

Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells

Abstract Methylglyoxal (MGO), a precursor of advanced glycation end products (AGEs), is regarded as a pivotal mediator of vascular damage in patients with diabetes. We have previously reported that MGO induces transcriptional changes compatible with p53 activation in cultured human endothelial cells...

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Bibliographic Details
Main Authors: Xinmiao Zhang, Angelica Rodriguez-Niño, Diego O. Pastene, Prama Pallavi, Jacob van den Born, Stephan J. L. Bakker, Bernhard K. Krämer, Benito A. Yard
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-87561-9

Internet

https://doi.org/10.1038/s41598-021-87561-9

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