Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells

Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells

Abstract Background Intestinal epithelial cells derived from human pluripotent stem cells (hPSCs) are generally maintained and cultured as organoids in vitro because they do not exhibit adhesion when cultured. However, the three-dimensional structure of organoids makes their use in regenerative medi...

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Bibliographic Details
Main Authors: JunLong Chen, Shinichiro Horiuchi, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Tomoki Arai, Kenichi Morinaga, Tohru Kimura, Tohru Kiyono, Hidenori Akutsu, Seiichi Ishida, Akihiro Umezawa
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchyme
Intestinal stem cells
Pluripotent stem cells
Organoids
Trophocytes
GREM1
Online Access:https://doi.org/10.1186/s13287-023-03629-5

Internet

https://doi.org/10.1186/s13287-023-03629-5

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