Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells

Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells

Abstract Background Intestinal epithelial cells derived from human pluripotent stem cells (hPSCs) are generally maintained and cultured as organoids in vitro because they do not exhibit adhesion when cultured. However, the three-dimensional structure of organoids makes their use in regenerative medi...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: JunLong Chen, Shinichiro Horiuchi, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Tomoki Arai, Kenichi Morinaga, Tohru Kimura, Tohru Kiyono, Hidenori Akutsu, Seiichi Ishida, Akihiro Umezawa
स्वरूप: लेख
भाषा:English
प्रकाशित: BMC 2024-01-01
श्रृंखला:Stem Cell Research & Therapy
विषय:
Mesenchyme
Intestinal stem cells
Pluripotent stem cells
Organoids
Trophocytes
GREM1
ऑनलाइन पहुंच:https://doi.org/10.1186/s13287-023-03629-5

इंटरनेट

https://doi.org/10.1186/s13287-023-03629-5

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