Synthesis of Pyrrolo[3,4-<i>b</i>]pyridin-5-ones via Multicomponent Reactions and In Vitro–In Silico Studies Against SiHa, HeLa, and CaSki Human Cervical Carcinoma Cell Lines

Synthesis of Pyrrolo[3,4-<i>b</i>]pyridin-5-ones via Multicomponent Reactions and In Vitro–In Silico Studies Against SiHa, HeLa, and CaSki Human Cervical Carcinoma Cell Lines

A series of 12 polysubstituted pyrrolo[3,4-<i>b</i>]pyridin-5-ones were synthesized via a one-pot cascade process (Ugi&#8722;3CR/<i>aza</i> Diels-Alder/<i>N</i>-acylation/decarboxylation/dehydration) and studied in vitro using human epithelial cervical carcino...

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Bibliographic Details
Main Authors: Daniel Segura-Olvera, Ailyn N. García-González, Ivette Morales-Salazar, Alejandro Islas-Jácome, Yareli Rojas-Aguirre, Ilich A. Ibarra, Erik Díaz-Cervantes, Sofía Lizeth Alcaraz-Estrada, Eduardo González-Zamora
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
pyrrolo[3,4-<i>b</i>]pyridin-5-ones
paclitaxel
αβ-tubulin
cervical cancer
SiHa
HeLa
Caski
molecular docking
QSAR
pharmacophore model
Online Access:https://www.mdpi.com/1420-3049/24/14/2648

Internet

https://www.mdpi.com/1420-3049/24/14/2648

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