A validated liquid chromatography-tandem mass spectrometry assay for the analysis of isoniazid and its metabolite acetyl-isoniazid in urine

A validated liquid chromatography-tandem mass spectrometry assay for the analysis of isoniazid and its metabolite acetyl-isoniazid in urine

Introduction: Isoniazid (INH) is one of the most effective and potent first-line anti-tubercular drug. INH is also effectively administered as a preventative monotherapy and has been shown to significantly reduce TB incidence. INH is primarily metabolised to acetyl-isoniazid (AcINH) in the liver. Ac...

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Bibliographic Details
Main Authors: Sydwell Poulo Maputla, Willem Van Dalen, Anton Joubert, Jennifer Norman, Sandra Castel, Marthinus van der Merwe, Lubbe Wiesner
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Journal of Mass Spectrometry and Advances in the Clinical Lab
Subjects:
Isoniazid
Acetyl-isoniazid
Solid phase extraction
LC-MS/MS
Urine
Validation
Online Access:http://www.sciencedirect.com/science/article/pii/S2667145X24000087

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http://www.sciencedirect.com/science/article/pii/S2667145X24000087

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