Comparison of 1-Palmitoyl-2-Linoleoyl-3-Acetyl-Rac-Glycerol-Loaded Self-Emulsifying Granule and Solid Self-Nanoemulsifying Drug Delivery System: Powder Property, Dissolution and Oral Bioavailability

Comparison of 1-Palmitoyl-2-Linoleoyl-3-Acetyl-Rac-Glycerol-Loaded Self-Emulsifying Granule and Solid Self-Nanoemulsifying Drug Delivery System: Powder Property, Dissolution and Oral Bioavailability

The main objective of this study was to compare the powder property, dissolution and bioavailability of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG)-loaded self-emulsifying granule system (SEGS) and solid self-nanoemulsifying drug delivery system (SNEDDS). Various SEGS formulations were prep...

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Bibliographic Details
Main Authors: Dong Shik Kim, Jung Suk Kim, Soo-Jeong Lim, Jong Oh Kim, Chul Soon Yong, Han-Gon Choi, Sung Giu Jin
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Pharmaceutics
Subjects:
oily liquid drug
1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol
self-emulsifying granule system
fluid bed granulation
flow ability
oral bioavailability
Online Access:https://www.mdpi.com/1999-4923/11/8/415

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https://www.mdpi.com/1999-4923/11/8/415

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