S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression

S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression

Global DNA hypomethylation is a characteristic feature of colorectal carcinoma (CRC). The tumor inhibitory effect of S-adenosylmethionine (SAM) methyl donor has been described in certain cancers including CRC. However, the molecular impact of SAM treatment on CRC cell lines with distinct genetic fea...

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Bibliographic Details
Main Authors: Sára Zsigrai, Alexandra Kalmár, Zsófia B. Nagy, Barbara K. Barták, Gábor Valcz, Krisztina A. Szigeti, Orsolya Galamb, Titanilla Dankó, Anna Sebestyén, Gábor Barna, Vanessza Szabó, Orsolya Pipek, Anna Medgyes-Horváth, István Csabai, Zsolt Tulassay, Péter Igaz, István Takács, Béla Molnár
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
colorectal cancer
S-adenosylmethionine
genomic stability
EMT
DNA methylation
epigenetics
Online Access:https://www.mdpi.com/2073-4409/9/8/1864

Internet

https://www.mdpi.com/2073-4409/9/8/1864

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