An improved medium formulation for efficient ex vivo gene editing, expansion and engraftment of hematopoietic stem and progenitor cells

An improved medium formulation for efficient ex vivo gene editing, expansion and engraftment of hematopoietic stem and progenitor cells

Gene editing has emerged as a powerful tool for the therapeutic correction of monogenic diseases. CRISPR-Cas9 applied to hematopoietic stem and progenitor cells (HSPCs) has shown great promise in proof-of-principle preclinical studies to treat hematological disorders, and clinical trials using these...

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Bibliographic Details
Main Authors: Rajeev Rai, Asma Naseem, Winston Vetharoy, Zohar Steinberg, Adrian J. Thrasher, Giorgia Santilli, Alessia Cavazza
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
gene editing
hematopoietic stem cells
cell culture
culture medium
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123000244

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http://www.sciencedirect.com/science/article/pii/S2329050123000244

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