Dnmt3a is an epigenetic mediator of adipose insulin resistance

Dnmt3a is an epigenetic mediator of adipose insulin resistance

Insulin resistance results from an intricate interaction between genetic make-up and environment, and thus may be orchestrated by epigenetic mechanisms like DNA methylation. Here, we demonstrate that DNA methyltransferase 3a (Dnmt3a) is both necessary and sufficient to mediate insulin resistance in...

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Bibliographic Details
Main Authors: Dongjoo You, Emma Nilsson, Danielle E Tenen, Anna Lyubetskaya, James C Lo, Rencong Jiang, Jasmine Deng, Brian A Dawes, Allan Vaag, Charlotte Ling, Evan D Rosen, Sona Kang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
adipocyte
insulin resistance
epigenetic
Online Access:https://elifesciences.org/articles/30766

Internet

https://elifesciences.org/articles/30766

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