13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico.

13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico.

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The biological activities of dehydrocostus lactone and its analogues are suggested to be mediated by the lactone ring and α,β-methylene-γ-lactone. However, few studies exist on the structure-activity relationship of 13-amino derivatives of dehydrocostus latone. In this study new 13-amino derivatives...

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Bibliographic Details
Main Authors: Douglas Kemboi, Moses K Langat, Xavier Siwe-Noundou, Tendamudzimu Tshiwawa, Rui W M Krause, Candace Davison, Christie Jane Smit, Jo-Anne de la Mare, Vuyelwa Jacqueline Tembu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0271389

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https://doi.org/10.1371/journal.pone.0271389

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