Interaction between Wnt/β-catenin signaling pathway and EMT pathway mediates the mechanism of sunitinib resistance in renal cell carcinoma

Interaction between Wnt/β-catenin signaling pathway and EMT pathway mediates the mechanism of sunitinib resistance in renal cell carcinoma

Abstract Background Targeted drugs are the main methods of RCC treatment. However, drug resistance is common in RCC patients, in-depth study of the drug-resistant mechanism is essential. Methods We constructed sunitinib resistant and Twist overexpressed A498 cells, and studied its mechanisms in vitr...

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Bibliographic Details
Main Authors: Fangzhen Cai, Jianwei Li, Yanmei Zhang, Sihuai Huang, Wenbin Liu, Weifeng Zhuo, Chengzhi Qiu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Cancer
Subjects:
Wnt
β-catenin
EMT
Sunitinib resistance
Renal cell carcinoma
Targeted therapy
Online Access:https://doi.org/10.1186/s12885-024-11907-5

Internet

https://doi.org/10.1186/s12885-024-11907-5

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