The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement.

The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement.

Nef is a multifunctional HIV-1 protein that accelerates progression to AIDS, and enhances the infectivity of progeny viruses through a mechanism that is not yet understood. Here, we show that the small molecule compound 2c reduces Nef-mediated viral infectivity enhancement. When added to viral produ...

Full description

Bibliographic Details
Main Authors: Nopporn Chutiwitoonchai, Masateru Hiyoshi, Philip Mwimanzi, Takamasa Ueno, Akio Adachi, Hirotaka Ode, Hironori Sato, Oliver T Fackler, Seiji Okada, Shinya Suzu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22110726/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22110726/?tool=EBI

Similar Items