HPV16 oncoproteins induce MMPs/RECK-TIMP-2 imbalance in primary keratinocytes: possible implications in cervical carcinogenesis.

Cervical cancer is the third most common cancer in women worldwide. Persistent infection with high-risk HPV types, principally HPV16 and 18 is the main risk factor for the development of this malignancy. However, the onset of invasive tumor occurs many years after initial exposure in a minority of i...

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Main Authors: Laura Beatriz da Silva Cardeal, Enrique Boccardo, Lara Termini, Tatiana Rabachini, Maria Antonieta Andreoli, Celso di Loreto, Adhemar Longatto Filho, Luisa Lina Villa, Silvya Stuchi Maria-Engler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3306414?pdf=render