Combining laser microdissection and microRNA expression profiling to unmask microRNA signatures in complex tissues

Neglecting tissue heterogeneity during the analysis of microRNA (miRNA) levels results in average signals from an unknown mixture of different cell types that are difficult to interpret. Here we demonstrate the technical requirements needed to obtain high-quality, quantitative miRNA expression infor...

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Bibliographic Details
Main Authors: Susanna Skalicky, Peter J Zwiers, Timara Kuiper, Elisabeth Schraml, Matthias Hackl, Grietje Molema
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:BioTechniques
Subjects:
Online Access:https://www.future-science.com/doi/10.2144/btn-2019-0032