The Leishmania donovani Ortholog of the Glycosylphosphatidylinositol Anchor Biosynthesis Cofactor PBN1 Is Essential for Host Infection

The Leishmania donovani Ortholog of the Glycosylphosphatidylinositol Anchor Biosynthesis Cofactor PBN1 Is Essential for Host Infection

ABSTRACT Visceral leishmaniasis is a deadly infectious disease caused by Leishmania donovani, a kinetoplastid parasite for which no licensed vaccine is available. To identify potential vaccine candidates, we systematically identified genes encoding putative cell surface and secreted proteins essenti...

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Bibliographic Details
Main Authors: Adam Roberts, Rupa Nagar, Cordelia Brandt, Katherine Harcourt, Simon Clare, Michael A. J. Ferguson, Gavin J. Wright
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
glycophosphatidylinositol biosynthesis
parasitology
mass spectrometry
leishmaniasis
enzyme
bioluminescence
Online Access:https://journals.asm.org/doi/10.1128/mbio.00433-22

Internet

https://journals.asm.org/doi/10.1128/mbio.00433-22

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