IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models

IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models

Breast cancer stem cells (BCSCs) are responsible for tumour recurrence and therapy resistance. We have established primary BCSC cultures from human tumours of triple-negative breast cancer (TNBC), a subgroup of breast cancer likely driven by BCSCs. Primary BCSCs produce xenografts that phenocopy the...

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Bibliographic Details
Main Authors: Francesca Ferraro, Anja Steinle, Harini Narasimhan, Andreas Bleilevens, Paula-Marie Stolzenberg, Till Braunschweig, Elmar Stickeler, Jochen Maurer
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
IRAK2
NF-κB
ERK
triple-negative breast cancer
breast cancer stem cells
endoplasmic reticulum stress
Online Access:https://www.mdpi.com/1422-0067/24/3/2520

Internet

https://www.mdpi.com/1422-0067/24/3/2520

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