Zoledronic Acid Blocks Overactive Kir6.1/SUR2-Dependent K<sub>ATP</sub> Channels in Skeletal Muscle and Osteoblasts in a Murine Model of Cantú Syndrome

Zoledronic Acid Blocks Overactive Kir6.1/SUR2-Dependent K<sub>ATP</sub> Channels in Skeletal Muscle and Osteoblasts in a Murine Model of Cantú Syndrome

Cantú syndrome (CS) is caused by the gain of function mutations in the <i>ABCC9</i> and <i>KCNJ8</i> genes encoding, respectively, for the sulfonylureas receptor type 2 (SUR2) and the inwardly rectifier potassium channel 6.1 (Kir6.1) of the ATP-sensitive potassium (KATP) chan...

Full description

Bibliographic Details
Main Authors: Rosa Scala, Fatima Maqoud, Conor McClenaghan, Theresa M. Harter, Maria Grazia Perrone, Antonio Scilimati, Colin G. Nichols, Domenico Tricarico
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
Cantú syndrome
rare disease
ATP-sensitive potassium channel
skeletal muscle
glibenclamide
patch clamp
Online Access:https://www.mdpi.com/2073-4409/12/6/928

Internet

https://www.mdpi.com/2073-4409/12/6/928

Similar Items