Rosmarinic acid, a natural polyphenol, has a potential pro-oxidant risk via NADH-mediated oxidative DNA damage

Rosmarinic acid, a natural polyphenol, has a potential pro-oxidant risk via NADH-mediated oxidative DNA damage

Abstract Background Rosmarinic acid (RA) has a wide range of beneficial effects on human health. On the other hand, RA has been reported to induce metal-mediated reactive oxygen species (ROS) generation and DNA damage. However, its mechanism remains unknown. In this study, to clarify the underlying...

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Bibliographic Details
Main Authors: Hatasu Kobayashi, Yuichiro Hirao, Shosuke Kawanishi, Shinya Kato, Yurie Mori, Mariko Murata, Shinji Oikawa
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Genes and Environment
Subjects:
Rosmarinic acid
DNA damage
Reactive oxygen species
Copper
NADH
8-oxo-7,8-dihydro-2’-deoxyguanosine
Online Access:https://doi.org/10.1186/s41021-024-00307-7

Internet

https://doi.org/10.1186/s41021-024-00307-7

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