The Secretome of Parental and Bone Metastatic Breast Cancer Elicits Distinct Effects in Human Osteoclast Activity after Activation of β2 Adrenergic Signaling

The Secretome of Parental and Bone Metastatic Breast Cancer Elicits Distinct Effects in Human Osteoclast Activity after Activation of β2 Adrenergic Signaling

The sympathetic nervous system (SNS), particularly through the β2 adrenergic receptor (β2-AR), has been linked with breast cancer (BC) and the development of metastatic BC, specifically in the bone. Nevertheless, the potential clinical benefits of exploiting β2-AR antagonists as a treatment for BC a...

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Bibliographic Details
Main Authors: Francisco Conceição, Daniela M. Sousa, Sofia Tojal, Catarina Lourenço, Carina Carvalho-Maia, Helena Estevão-Pereira, João Lobo, Marina Couto, Mette M. Rosenkilde, Carmen Jerónimo, Meriem Lamghari
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomolecules
Subjects:
breast cancer
beta-adrenergic
sympathetic nervous system
osteoclast
proteomic
Online Access:https://www.mdpi.com/2218-273X/13/4/622

Internet

https://www.mdpi.com/2218-273X/13/4/622

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