Non-Modified CpG Oligodeoxynucleotide Forming Guanine-Quadruplex Structure Complexes with ε-Poly-<sub>L</sub>-Lysine Induce Antibody Production as Vaccine Adjuvants

Non-Modified CpG Oligodeoxynucleotide Forming Guanine-Quadruplex Structure Complexes with ε-Poly-<sub>L</sub>-Lysine Induce Antibody Production as Vaccine Adjuvants

Unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides (CpG ODNs) induce inflammatory cytokines and type I interferons (IFNs) to activate the immune system. To apply CpG ODNs as vaccine adjuvants, the cellular uptake and stability of phosphodiester-based, non-modified ODNs require further i...

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Bibliographic Details
Main Authors: Dandan Zhao, Anh Thi Tram Tu, Miwako Shobo, Nguyen Bui Thao Le, Chiaki Yoshikawa, Kazuhisa Sugai, Yoji Hakamata, Tomohiko Yamazaki
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biomolecules
Subjects:
guanine quadruplex
CpG oligodeoxynucleotides
ε-poly-<sub>L</sub>-lysine
immune stimulation
cytokine induction
Online Access:https://www.mdpi.com/2218-273X/12/12/1868

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https://www.mdpi.com/2218-273X/12/12/1868

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