Repurposing Quinacrine for Treatment of Malignant Mesothelioma: In-Vitro Therapeutic and Mechanistic Evaluation

Repurposing Quinacrine for Treatment of Malignant Mesothelioma: In-Vitro Therapeutic and Mechanistic Evaluation

Malignant mesothelioma (MM) is a rare type of cancer primarily affecting mesothelial cells lining the pleural cavity. In this study, we propose to repurpose quinacrine (QA), a widely approved anti-malarial drug, for Malignant Pleural Mesothelioma (MPM) treatment. QA demonstrates high degree of cytot...

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Bibliographic Details
Main Authors: Nishant S. Kulkarni, Bhuvaneshwar Vaidya, Vineela Parvathaneni, Debarati Bhanja, Vivek Gupta
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
drug repurposing
quinacrine
malignant pleural mesothelioma
autophagy
apoptosis
Online Access:https://www.mdpi.com/1422-0067/21/17/6306

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https://www.mdpi.com/1422-0067/21/17/6306

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