An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation

An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation

Introduction: Hypoxia is one of the important reasons for the poor therapeutic efficacy of current pancreatic cancer treatment, and the dense stroma of pancreatic cancer restricts the diffusion of oxygen within the tumor. Methods: A responsive oxygen-self-supplying adv-miRT-CAT-KR (adv-MCK) cascade...

Full description

Bibliographic Details
Main Authors: Yu Chen, Jialun Wang, Ying Huang, Jianzhuang Wu, Yue Wang, Aotian Chen, Qiyuan Guo, Yixuan Zhang, Shu Zhang, Lei Wang, Xiaoping Zou, Xihan Li
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Pharmacological Research
Subjects:
Oncolytic system
Hypoxia
Photodynamic therapy
Immune activation
Pancreatic tumor
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823004097

Internet

http://www.sciencedirect.com/science/article/pii/S1043661823004097

Similar Items