Amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral density
There is general consent that with decreasing bone mineral density the amount of marrow adipose tissue increases. While image-based techniques, claim an increase in saturated fatty acids responsible for this effect, this study shows an increase in both saturated and unsaturated fatty acids in the bo...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
2023-02-01
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| Series: | EXCLI Journal : Experimental and Clinical Sciences |
| Subjects: | |
| Online Access: | https://www.excli.de/index.php/excli/article/view/5843 |
| _version_ | 1827963964947955712 |
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| author | Sabrina Ehnert Anna J. Schreiner Claudine Seeliger Josef Ecker Fabian Springer Gerhard Liebisch Philipp Hemmann Tina Histing Andreas K. Nussler |
| author_facet | Sabrina Ehnert Anna J. Schreiner Claudine Seeliger Josef Ecker Fabian Springer Gerhard Liebisch Philipp Hemmann Tina Histing Andreas K. Nussler |
| author_sort | Sabrina Ehnert |
| collection | DOAJ |
| description | There is general consent that with decreasing bone mineral density the amount of marrow adipose tissue increases. While image-based techniques, claim an increase in saturated fatty acids responsible for this effect, this study shows an increase in both saturated and unsaturated fatty acids in the bone marrow. Using fatty acid methyl ester gas chromatography-mass spectrometry, characteristic fatty acid patterns for patients with normal BMD (N = 9), osteopenia (N = 12), and osteoporosis (N = 9) have been identified, which differ between plasma, red bone marrow and yellow bone marrow. Selected fatty acids, e.g. FA10:0, FA14:1, or FA16:1 n-7 in the bone marrow or FA18:0, FA18:1 n-9, FA18:1 n-7, FA20:0, FA20:1 n-9, or FA20:3 n-6 in the plasma, correlated with osteoclast activity, suggesting a possible mechanism how these fatty acids may interfere with BMD. Although several fatty acids correlated well with the osteoclast activity and BMD, there was not a single fatty acid contained in our fatty acid profile that can be claimed for controlling BMD, a fact that may be attributed to the genetic heterogeneity of the patients. |
| first_indexed | 2024-04-09T17:06:27Z |
| format | Article |
| id | doaj.art-6efc02c67cab4868acc26176789e9ce0 |
| institution | Directory Open Access Journal |
| issn | 1611-2156 |
| language | English |
| last_indexed | 2024-04-09T17:06:27Z |
| publishDate | 2023-02-01 |
| publisher | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund |
| record_format | Article |
| series | EXCLI Journal : Experimental and Clinical Sciences |
| spelling | doaj.art-6efc02c67cab4868acc26176789e9ce02023-04-20T12:35:36ZengIfADo - Leibniz Research Centre for Working Environment and Human Factors, DortmundEXCLI Journal : Experimental and Clinical Sciences1611-21562023-02-012220722010.17179/excli2023-58435282Amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral densitySabrina Ehnert0https://orcid.org/0000-0003-4347-1702Anna J. Schreiner1https://orcid.org/0000-0001-8073-8176Claudine Seeliger2https://orcid.org/0000-0002-7631-444XJosef Ecker3https://orcid.org/0000-0003-4799-0788Fabian Springer4https://orcid.org/0000-0003-4451-7127Gerhard Liebisch5https://orcid.org/0000-0003-4886-0811Philipp Hemmann6https://orcid.org/0000-0002-0535-5359Tina Histing7https://orcid.org/0000-0002-6955-2001Andreas K. Nussler8https://orcid.org/0000-0002-6666-6791Siegfried-Weller Institute for Trauma Research, BG Trauma Center, University of Tuebingen, Schnarrenbergstrasse 95, 72070 Tuebingen, Germany. Tel: +49-7071-606 1065. E-mail: sabrina.ehnert@med.uni-tuebingen.deSiegfried-Weller Institute for Trauma Research, BG Trauma Center, University of Tuebingen, Tuebingen, Germany; RKH Orthopedic Clinic Markgroeningen, 71706 Markgroeningen, GermanyZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, GermanyZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital and BG Trauma Center, University of Tuebingen, Tuebingen, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, GermanySiegfried-Weller Institute for Trauma Research, BG Trauma Center, University of Tuebingen, Tuebingen, GermanySiegfried-Weller Institute for Trauma Research, BG Trauma Center, University of Tuebingen, Tuebingen, GermanySiegfried-Weller Institute for Trauma Research, BG Trauma Center, University of Tuebingen, Tuebingen, GermanyThere is general consent that with decreasing bone mineral density the amount of marrow adipose tissue increases. While image-based techniques, claim an increase in saturated fatty acids responsible for this effect, this study shows an increase in both saturated and unsaturated fatty acids in the bone marrow. Using fatty acid methyl ester gas chromatography-mass spectrometry, characteristic fatty acid patterns for patients with normal BMD (N = 9), osteopenia (N = 12), and osteoporosis (N = 9) have been identified, which differ between plasma, red bone marrow and yellow bone marrow. Selected fatty acids, e.g. FA10:0, FA14:1, or FA16:1 n-7 in the bone marrow or FA18:0, FA18:1 n-9, FA18:1 n-7, FA20:0, FA20:1 n-9, or FA20:3 n-6 in the plasma, correlated with osteoclast activity, suggesting a possible mechanism how these fatty acids may interfere with BMD. Although several fatty acids correlated well with the osteoclast activity and BMD, there was not a single fatty acid contained in our fatty acid profile that can be claimed for controlling BMD, a fact that may be attributed to the genetic heterogeneity of the patients.https://www.excli.de/index.php/excli/article/view/5843bone mineral densityfatty acid compositionbone marrowsaturated fatty acidsunsaturated fatty acidstartrate-resistant acidic phosphatase (trap5b) |
| spellingShingle | Sabrina Ehnert Anna J. Schreiner Claudine Seeliger Josef Ecker Fabian Springer Gerhard Liebisch Philipp Hemmann Tina Histing Andreas K. Nussler Amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral density EXCLI Journal : Experimental and Clinical Sciences bone mineral density fatty acid composition bone marrow saturated fatty acids unsaturated fatty acids tartrate-resistant acidic phosphatase (trap5b) |
| title | Amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral density |
| title_full | Amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral density |
| title_fullStr | Amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral density |
| title_full_unstemmed | Amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral density |
| title_short | Amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral density |
| title_sort | amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral density |
| topic | bone mineral density fatty acid composition bone marrow saturated fatty acids unsaturated fatty acids tartrate-resistant acidic phosphatase (trap5b) |
| url | https://www.excli.de/index.php/excli/article/view/5843 |
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