The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa

The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa

In mice, rats, dogs and humans, the growth and function of sebaceous glands and eyelid Meibomian glands depend on the ectodysplasin signalling pathway. Mutation of genes encoding the ligand EDA, its transmembrane receptor EDAR and the intracellular signal transducer EDARADD leads to hypohidrotic ect...

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Bibliographic Details
Main Authors: Jorge del-Pozo, Denis J. Headon, James D. Glover, Ali Azar, Sonia Schuepbach-Mallepell, Mahmood F. Bhutta, Jon Riddell, Scott Maxwell, Elspeth Milne, Pascal Schneider, Michael Cheeseman
Format: Article
Language:English
Published: The Company of Biologists 2022-03-01
Series:Disease Models & Mechanisms
Subjects:
hypohidrotic ectodermal dysplasia
sparse and wavy hair rat
edaradd
fbxo11
mecom
edar
tabby mouse
Online Access:http://dmm.biologists.org/content/15/3/dmm049034

Internet

http://dmm.biologists.org/content/15/3/dmm049034

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