The effect of Abi3 locus deletion on the progression of Alzheimer’s disease-related pathologies

The effect of Abi3 locus deletion on the progression of Alzheimer’s disease-related pathologies

Human genetics studies of Alzheimer’s disease (AD) have identified the ABI3 gene as a candidate risk gene for AD. Because ABI3 is highly expressed in microglia, the brain’s immune cells, it was suggested that ABI3 might impact AD pathogenesis by regulating the immune response. Recent studies suggest...

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Bibliographic Details
Main Authors: Hande Karahan, Daniel C. Smith, Byungwook Kim, Brianne McCord, Jordan Mantor, Sutha K. John, Md Mamun Al-Amin, Luke C. Dabin, Jungsu Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
ABI3
Alzheimer’s disease
microglia
inflammation
5xFAD
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1102530/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1102530/full

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