The effect of Abi3 locus deletion on the progression of Alzheimer’s disease-related pathologies

The effect of Abi3 locus deletion on the progression of Alzheimer’s disease-related pathologies

Human genetics studies of Alzheimer’s disease (AD) have identified the ABI3 gene as a candidate risk gene for AD. Because ABI3 is highly expressed in microglia, the brain’s immune cells, it was suggested that ABI3 might impact AD pathogenesis by regulating the immune response. Recent studies suggest...

Full description

Bibliographic Details
Main Authors:	Hande Karahan, Daniel C. Smith, Byungwook Kim, Brianne McCord, Jordan Mantor, Sutha K. John, Md Mamun Al-Amin, Luke C. Dabin, Jungsu Kim
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Series:	Frontiers in Immunology
Subjects:	ABI3 Alzheimer’s disease microglia inflammation 5xFAD
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1102530/full

Similar Items

Effects of SPI1-mediated transcriptome remodeling on Alzheimer’s disease-related phenotypes in mouse models of Aβ amyloidosis
by: Byungwook Kim, et al.
Published: (2024-05-01)

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology
by: Kristine M. Tran, et al.
Published: (2025-01-01)

Oral Administration of <i>Euonymus alatus</i> Leaf Extract Ameliorates Alzheimer’s Disease Phenotypes in 5xFAD Transgenic Mice
by: Yoonsu Kim, et al.
Published: (2024-02-01)

Amyloid-β neuropathology induces bone loss in male mice by suppressing bone formation and enhancing bone resorption
by: Younghun Jung, et al.
Published: (2024-06-01)

Consequences of Amyloid‐β Deficiency for the Liver
by: Gayane Hrachia Buniatian, et al.
Published: (2024-05-01)

Branched-Chain Amino Acids Are Linked with Alzheimer’s Disease-Related Pathology and Cognitive Deficits
by: Md Abu Bakkar Siddik, et al.
Published: (2022-11-01)

Long-Term Treatment of Cuban Policosanol Attenuates Abnormal Oxidative Stress and Inflammatory Response via Amyloid Plaques Reduction in 5xFAD Mice
by: Jin-Ho Kim, et al.
Published: (2021-08-01)

Behavioral and pathological characteristics of 5xFAD female mice in the early stage
by: Chenlu Zhu, et al.
Published: (2025-02-01)

Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse
by: Simone M. Crivelli, et al.
Published: (2023-08-01)

Fecal Microbiota Transplantation Reduces Pathology and Improves Cognition in a Mouse Model of Alzheimer’s Disease
by: Shalini Elangovan, et al.
Published: (2022-12-01)

Age-Related Modifications of Electroencephalogram Coherence in Mice Models of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis
by: Vasily Vorobyov, et al.
Published: (2023-04-01)

The impacts of sex and the 5xFAD model of Alzheimer’s disease on the sleep and spatial learning responses to feeding time
by: Katrina J. Campbell, et al.
Published: (2024-07-01)

A clathrin mediated endocytosis scaffolding protein, Intersectin 1, changes in an isoform, brain region, and sex specific manner in Alzheimer’s disease
by: Sierra Jaye, et al.
Published: (2024-06-01)

Attenuation of Spatial Memory in 5xFAD Mice by Halting Cholinesterases, Oxidative Stress and Neuroinflammation Using a Cyclopentanone Derivative
by: Rahim Ullah, et al.
Published: (2020-10-01)

Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model
by: Mariia Ivanova, et al.
Published: (2024-02-01)

A systematic review and meta-analysis of tau phosphorylation in mouse models of familial Alzheimer's disease
by: Malamati Kourti, et al.
Published: (2024-03-01)

Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered
by: Alex B. Speers, et al.
Published: (2024-03-01)

Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer’s Disease
by: Erming Wang, et al.
Published: (2024-01-01)

Voluntary Wheel Running Did Not Alter Gene Expression in 5xfad Mice, but in Wild-Type Animals Exclusively after One-Day of Physical Activity
by: Anna Wierczeiko, et al.
Published: (2021-03-01)

Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits and Gliosis in the 5xFAD Mouse Model of Alzheimer’s Disease
by: Zackary Bowers, et al.
Published: (2021-10-01)

Contribution of Chronic Sleep Deprivation to Age-Related Neurodegeneration in a Mouse Model of Familial Alzheimer’s Disease (5xFAD)
by: Maria O. Klimenko, et al.
Published: (2023-06-01)

Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
by: Dorit Farfara, et al.
Published: (2023-07-01)

Apolipoprotein E4 interferes with lipid metabolism to exacerbate depression‐like behaviors in 5xFAD mice
by: Yanju Gong, et al.
Published: (2024-06-01)

Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer’s Disease in a Preclinical Model: A Therapeutic Opportunity
by: Dina Medina-Vera, et al.
Published: (2020-11-01)

Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease
by: Karthivashan Govindarajan, et al.
Published: (2023-07-01)

Qi-fu-yin attenuated cognitive disorders in 5xFAD mice of Alzheimer's disease animal model by regulating immunity
by: Xiuzhao Yang, et al.
Published: (2023-06-01)

Long-Term Administration of <i>Vespa velutina nigrithorax</i> Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic Mice
by: Yoon Ah Jeong, et al.
Published: (2023-03-01)

Collective Adaptive Responses Through Coping and Sensemaking Under Stress
by: Jungsu Kim, et al.
Published: (2023-10-01)

Neuroprotective properties of anti-apoptotic BCL-2 proteins in 5xFAD mouse model of Alzheimer’s disease
by: D. Chernyuk, et al.
Published: (2023-06-01)

Exploring the anti-inflammatory effects of curcumin encapsulated within ferritin nanocages: a comprehensive in vivo and in vitro study in Alzheimer’s disease
by: Carlo Morasso, et al.
Published: (2024-11-01)

Comprehensive Analysis of the 5xFAD Mouse Model of Alzheimer’s Disease Using dMRI, Immunohistochemistry, and Neuronal and Glial Functional Metabolic Mapping
by: Emil W. Westi, et al.
Published: (2024-10-01)

Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice
by: Geetika Nehra, et al.
Published: (2024-03-01)

A Transgenic 5xFAD-M Line of Mice for Dendritic Spine Morphology Analysis in Alzheimer’s Disease
by: Anastasiia Ilina, et al.
Published: (2023-02-01)

Suspension TRAPping Filter (sTRAP) Sample Preparation for Quantitative Proteomics in the Low µg Input Range Using a Plasmid DNA Micro-Spin Column: Analysis of the Hippocampus from the 5xFAD Alzheimer’s Disease Mouse Model
by: Evangelia Thanou, et al.
Published: (2023-04-01)

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer’s disease
by: Annett Boeddrich, et al.
Published: (2023-07-01)

"That is an interesting question!" Oddball Interview Questions and Organizational Personality Perceptions
by: Don Zhang, et al.
Published: (2023-05-01)

Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice
by: Kathrin Gnoth, et al.
Published: (2022-03-01)

Urban social conflict /
by: 380932 McCord, Arline, et al.
Published: (1977)

Multi-Phase Joint-Angle Trajectory Generation Inspired by Dog Motion for Control of Quadruped Robot
by: Jungsu Choi
Published: (2021-09-01)

Comparison of Automated Machine Learning Model Performance for Predicting Chlorophyll-a Concentration according to Measurement Frequency of Input Data
by: Jungsu Park
Published: (2023-04-01)