Structural and functional plasticity of subcellular tethering, targeting and processing of RPGRIP1 by RPGR isoforms

Structural and functional plasticity of subcellular tethering, targeting and processing of RPGRIP1 by RPGR isoforms

Summary Mutations affecting the retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1) interactome cause syndromic retinal dystrophies. RPGRIP1 interacts with the retinitis pigmentosa GTPase regulator (RPGR) through a domain homologous to RCC1 (RHD), a nucleotide exchange factor of Ra...

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Bibliographic Details
Main Authors: Hemangi Patil, Mallikarjuna R. Guruju, Kyoung-in Cho, Haiqing Yi, Andrew Orry, Hyesung Kim, Paulo A. Ferreira
Format: Article
Language:English
Published: The Company of Biologists 2012-02-01
Series:Biology Open
Subjects:
protein targeting
RPGRIP1
RPGR
protein aggregation
degeneration
photoreceptor
kidney cells
Online Access:http://bio.biologists.org/content/1/2/140

Internet

http://bio.biologists.org/content/1/2/140

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