Optimization of high expression and purification of recombinant streptokinase and in vitro evaluation of its thrombolytic activity

Background: Streptokinase (SK) is a potent plasminogen activator naturally produced by beta-hemolytic streptococcus bacteria and used as a thrombolytic drug. Objectives: Optimize high yield production of recombinant streptokinase (rSK) in Escherichia coli and evaluate its thrombolytic activity. Meth...

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Bibliographic Details
Main Authors: Ehab El-Dabaa, Hend Okasha, Safia Samir, Sami Mohamed Nasr, Hadeer Adel El-Kalamawy, Mohamed Ali Saber
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Arabian Journal of Chemistry
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535222001150