Optimization of high expression and purification of recombinant streptokinase and in vitro evaluation of its thrombolytic activity

Optimization of high expression and purification of recombinant streptokinase and in vitro evaluation of its thrombolytic activity

Background: Streptokinase (SK) is a potent plasminogen activator naturally produced by beta-hemolytic streptococcus bacteria and used as a thrombolytic drug. Objectives: Optimize high yield production of recombinant streptokinase (rSK) in Escherichia coli and evaluate its thrombolytic activity. Meth...

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Bibliographic Details
Main Authors:	Ehab El-Dabaa, Hend Okasha, Safia Samir, Sami Mohamed Nasr, Hadeer Adel El-Kalamawy, Mohamed Ali Saber
Format:	Article
Language:	English
Published:	Elsevier 2022-05-01
Series:	Arabian Journal of Chemistry
Subjects:	Streptokinase Expression Refolding Purification Activity assays
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535222001150

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