Genome- and CD4+ T-cell methylome-wide association study of circulating trimethylamine-N-oxide in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN)

Genome- and CD4+ T-cell methylome-wide association study of circulating trimethylamine-N-oxide in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN)

Background: Trimethylamine-N-oxide (TMAO), an atherogenic metabolite species, has emerged as a possible new risk factor for cardiovascular disease. Animal studies have shown that circulating TMAO levels are regulated by genetic and environmental factors. However, large-scale human studies have faile...

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Bibliographic Details
Main Authors: Stella Aslibekyan, Marguerite R. Irvin, Bertha A. Hidalgo, Rodney T. Perry, Elias J. Jeyarajah, Erwin Garcia, Irina Shalaurova, Paul N. Hopkins, Michael A. Province, Hemant K. Tiwari, Jose M. Ordovas, Devin M. Absher, Donna K. Arnett
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Journal of Nutrition & Intermediary Metabolism
Subjects:
Atherosclerosis
Cardiovascular disease
Genetic
Epigenetic
Methylation
Trimethylamine-N-oxide
Online Access:http://www.sciencedirect.com/science/article/pii/S2352385917300051

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http://www.sciencedirect.com/science/article/pii/S2352385917300051

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