Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells

Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells

Abstract HELLS/LSH (Helicase, Lymphoid Specific) is a SNF2-like chromatin remodelling protein involved in DNA methylation. Its loss-of-function in humans causes humoral immunodeficiency, called ICF4 syndrome (Immunodeficiency, Centromeric Instability, Facial anomalies). Here we show by our newly gen...

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Bibliographic Details
Main Authors: Clara Cousu, Eléonore Mulot, Annie De Smet, Sara Formichetti, Damiana Lecoeuche, Jianke Ren, Kathrin Muegge, Matthieu Boulard, Jean-Claude Weill, Claude-Agnès Reynaud, Sébastien Storck
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41317-3

Internet

https://doi.org/10.1038/s41467-023-41317-3

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