Digoxin Derivatives Sensitize a <i>Saccharomyces cerevisiae</i> Mutant Strain to Fluconazole by Inhibiting Pdr5p

Digoxin Derivatives Sensitize a <i>Saccharomyces cerevisiae</i> Mutant Strain to Fluconazole by Inhibiting Pdr5p

The poor outcome of treatments for fungal infections is a consequence of the increasing incidence of resistance to antifungal agents, mainly due to the overexpression of efflux pumps. To surpass this mechanism of resistance, a substance able to inhibit these pumps could be administered in associatio...

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Bibliographic Details
Main Authors: Daniel Clemente de Moraes, Ana Claudia Tessis, Rodrigo Rollin-Pinheiro, Jefferson Luiz Princival, José Augusto Ferreira Perez Villar, Leandro Augusto Barbosa, Eliana Barreto-Bergter, Antônio Ferreira-Pereira
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Journal of Fungi
Subjects:
digoxin
efflux pump
fluconazole
Pdr5p
<i>Saccharomyces cerevisiae</i>
yeast
Online Access:https://www.mdpi.com/2309-608X/8/8/769

Internet

https://www.mdpi.com/2309-608X/8/8/769

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