Stress combined with loss of the Candida albicans SUMO protease Ulp2 triggers selection of aneuploidy via a two-step process.
A delicate balance between genome stability and instability ensures genome integrity while generating genetic diversity, a critical step for evolution. Indeed, while excessive genome instability is harmful, moderated genome instability can drive adaptation to novel environments by maximising genetic...
Main Authors: | Marzia Rizzo, Natthapon Soisangwan, Samuel Vega-Estevez, Robert Jordan Price, Chloe Uyl, Elise Iracane, Matt Shaw, Jan Soetaert, Anna Selmecki, Alessia Buscaino |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022-12-01
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Series: | PLoS Genetics |
Online Access: | https://doi.org/10.1371/journal.pgen.1010576 |
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