Evaluating a Causal Relationship between Complement Factor I Protein Level and Advanced Age-Related Macular Degeneration Using Mendelian Randomization

Evaluating a Causal Relationship between Complement Factor I Protein Level and Advanced Age-Related Macular Degeneration Using Mendelian Randomization

Purpose: Risk of advanced age-related macular degeneration (AAMD) is associated with rare genetic variants in the gene encoding complement factor I (CFI), which is associated with lower circulating CFI protein levels, but the nature of the relationship is unclear. Can genetic factors be used to infe...

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Bibliographic Details
Main Authors: Amy V. Jones, PhD, Stuart MacGregor, PhD, Xikun Han, PhD, James Francis, PhD, Claire Harris, PhD, David Kavanagh, MD, PhD, Andrew Lotery, MD, FRCOphth, Nadia Waheed, MD, MPH
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Ophthalmology Science
Subjects:
Advanced age-related macular degeneration
Biomarkers
CFI
Factor I
Genetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2666914522000355

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http://www.sciencedirect.com/science/article/pii/S2666914522000355

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