Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis

Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis

Abstract Background Neuromyelitis optica spectrum disorder (NMOSD), an autoimmune astrocytopathic disease associated with the anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions primarily located on the optic nerves and spinal cord. Tanshinone IIA (TSA), an active natura...

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Bibliographic Details
Main Authors: Ye Gong, Ya-ling Zhang, Zhen Wang, Huan-huan Song, Yuan-chu Liu, Ao-wei Lv, Li-li Tian, Wen-li Zhu, Ying Fu, Xiao-li Ding, Lang-jun Cui, Ya-ping Yan
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Neuroinflammation
Subjects:
Tanshinone IIA
Neuromyelitis optica spectrum disorder
Mouse model
Neuroinflammation
Neutrophil apoptosis
Online Access:http://link.springer.com/article/10.1186/s12974-020-01874-6

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http://link.springer.com/article/10.1186/s12974-020-01874-6

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