Unique osteogenic profile of bone marrow stem cells stimulated in perfusion bioreactor is Rho‐ROCK‐mediated contractility dependent

Unique osteogenic profile of bone marrow stem cells stimulated in perfusion bioreactor is Rho‐ROCK‐mediated contractility dependent

Abstract The fate determination of bone marrow mesenchymal stem/stromal cells (BMSC) is tightly regulated by mechanical cues, including fluid shear stress. Knowledge of mechanobiology in 2D culture has allowed researchers in bone tissue engineering to develop 3D dynamic culture systems with the pote...

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Bibliographic Details
Main Authors: Shuntaro Yamada, Mohammed A. Yassin, Francesco Torelli, Jan Hansmann, Jeremy B. A. Green, Thomas Schwarz, Kamal Mustafa
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Bioengineering & Translational Medicine
Subjects:
actomyosin contraction
bioreactor
bone tissue engineering
fluid shear stress
osteogenic differentiation
Rho GTPase signaling
Online Access:https://doi.org/10.1002/btm2.10509

Internet

https://doi.org/10.1002/btm2.10509

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