The Dual Role of Nod-like Receptors in Mucosal Innate Immunity and Chronic Intestinal Inflammation

The Dual Role of Nod-like Receptors in Mucosal Innate Immunity and Chronic Intestinal Inflammation

Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly conserved cytosolic pattern recognition receptors (PRRs) that play, in combination with Toll-like receptors (TLRs), a critical role in innate immunity and inflammation. These proteins are characterized by a central ol...

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Bibliographic Details
Main Authors: Daniele eCorridoni, Kristen eArseneau, Maria Grazia eCifone, Fabio eCominelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Immunology
Subjects:
Inflammation
innate immunity
IBD
nod-like receptors
inflammasome activation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00317/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00317/full

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