Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression.

Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression.

The relationship between cohesin-mediated chromatin looping and gene expression remains unclear. NIPBL and WAPL are two opposing regulators of cohesin activity; depletion of either is associated with changes in both chromatin folding and transcription across a wide range of cell types. However, a di...

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Bibliographic Details
Main Authors: Jennifer M Luppino, Andrew Field, Son C Nguyen, Daniel S Park, Parisha P Shah, Richard J Abdill, Yemin Lan, Rebecca Yunker, Rajan Jain, Karen Adelman, Eric F Joyce
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010528

Internet

https://doi.org/10.1371/journal.pgen.1010528

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