Development of Robust Tablet Formulations with Enhanced Drug Dissolution Profiles from Centrifugally-Spun Micro-Fibrous Solid Dispersions of Itraconazole, a BCS Class II Drug

Development of Robust Tablet Formulations with Enhanced Drug Dissolution Profiles from Centrifugally-Spun Micro-Fibrous Solid Dispersions of Itraconazole, a BCS Class II Drug

Fibre-based oral drug delivery systems are an attractive approach to addressing low drug solubility, although clear strategies for incorporating such systems into viable dosage forms have not yet been demonstrated. The present study extends our previous work on drug-loaded sucrose microfibres produc...

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Bibliographic Details
Main Authors: Stefania Marano, Manish Ghimire, Shahrzad Missaghi, Ali Rajabi-Siahboomi, Duncan Q. M. Craig, Susan A. Barker
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
centrifugal spinning
microfibre
amorphous solid dispersion
sucrose
poorly water-soluble drug
itraconazole
Online Access:https://www.mdpi.com/1999-4923/15/3/802

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https://www.mdpi.com/1999-4923/15/3/802

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