A hybrid model of mammalian cell cycle regulation.

The timing of DNA synthesis, mitosis and cell division is regulated by a complex network of biochemical reactions that control the activities of a family of cyclin-dependent kinases. The temporal dynamics of this reaction network is typically modeled by nonlinear differential equations describing th...

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Bibliographic Details
Main Authors: Rajat Singhania, R Michael Sramkoski, James W Jacobberger, John J Tyson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3037389?pdf=render